This interim report documents the application of a railroad classification yard design methodology to Boston and Maine's East Deerfield Yard Rehabiliation. Railroad classification yard design methodology study : East Deerfield Yard, a case study This : case study effort represents Phase 2 of a larger effort to develop a yard : design methodology, and. This interim report documents the application of a railroad classification : yard design methodology to CONRAIL's Elkhart Yard Rehabilitation. Railroad classification yard design methodology study Elkhart Yard Rehabilitation : a case study This case study entailed evaluation of the yard traffic capaci. This report documents the application of the railroad classification yard computer system methodology to Potomac Yard of the Richmond, Fredericksburg, and Potomac Railroad Company (RF&P). Railroad classification yard technology : computer system methodology : case study : Potomac Yard
A modified essentially non-oscillatory ( ENO) scheme is proposed, which recovers the correct order of accuracy for all the test problems with smooth initial conditions and gives comparable results with the original ENO schemes for discontinuous problems. Numerical experiments on the accuracy of ENO and modified ENO schemesįurther numerical experiments are made assessing an accuracy degeneracy phenomena. Taken together, we reported a novel mechanism for regulation of eNOS uncoupling by low SS via autophagy-mediated eNOS phosphorylation, which is implicated in geometrical nature of atherogenesis. Notably, although low SS had no influence on eNOS Ser1177 phosphorylation, whereas boosted eNOS Ser1177 phosphorylation by rapamycin were in favor of the eNOS recoupling through restoration of autophagic flux. In contrast, eNOS acetylation was not found to be regulated by low SS and autophagy. eNOS uncoupling might be ascribed to autophagic flux blockade because phosphorylation of eNOS Thr495 by low SS or PMA stimulation was also regulated by autophagy. Interestingly, low SS-induced NO reduction could be reversed by rapamycin, WYE-354 or ATG5 overexpression vector via restoration of autophagic flux, but not by N-acetylcysteine or apocynin. Autophagy markers such as LC3 II/I ratio, amount of Beclin1, as well as ULK1/Atg1 were increased during low SS exposure, whereas autophagic degradation of p62/SQSTM1 was markedly reduced, implying impaired autophagic flux. Furthermore, inhibition of eNOS by L-NAME conspicuously attenuated low SS-induced O 2 - releasing, indicating eNOS uncoupling. We found that low SS induced endothelial O 2 - burst, which was accompanied by reduced NO release. Therefore, this study aimed to investigate the modulation of autophagy on eNOS uncoupling induced by low SS exposure. Nevertheless, it is unclear whether autophagy plays a critical role in the regulation of eNOS uncoupling. Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O 2 - production. Uncoupled endothelial nitric oxide synthase ( eNOS) produces O 2 - instead of nitric oxide (NO). Zhang, Jun-Xia Qu, Xin-Liang Chu, Peng Xie, Du-Jiang Zhu, Lin-Lin Chao, Yue-Lin Li, Li Zhang, Jun-Jie Chen, Shao-Liang Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation. Subjects include: site location, economic analysis, yard capacity analysis, design of flat yards, overall configuration of hump yards, hump. This volume documents the procedures and methods associated with the design of railroad classification yards.
Volume I : Yard Design MethodsĭOT National Transportation Integrated Search
Railroad Classification Yard Technology Manual. Questionnaire was randomly distributed to 1200 students in their hostels out of which 67.66% was returned.… The survey was conducted in the Federal University of Technology Owerri ( FUTO), Nigeria with a view to identifying the rate and purpose of Internet use by students in other to be well positioned to provide effective Internet services to them. Dynamics of Internet Usage: A Case of Students of the Federal University of Technology Owerri ( FUTO) NigeriaĮRIC Educational Resources Information Center